THE PALM LABORATORY
Illuminating Host-Microbiota Interactions in Health and Disease
The Palm lab is an academic research laboratory within the Immunobiology department at the Yale School of Medicine, located in downtown New Haven, CT. Our overarching goal is to understand how microbiota - the trillions of microbes that live in and on us - interact with and influence their mammalian hosts. Our work particularly emphasizes the development of new technologies to deconvolute complex host-microbiota communication networks and reveal causal roles for the microbiota in human health and disease.
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions.
Chen H#, Rosen CE, González-Hernández JA, Song D, Potempa J, Ring AM, Palm NW#. Cell. 2023 Jun 8:S0092-8674(23)00543-3. Online ahead of print. doi: 10.1016/j.cell.2023.05.024
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites.
Cao Y, Oh J, Xu M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Science, 378(6618):eabm3233. doi: 10.1126/science.abm3233.