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RESEARCH

Illuminating Host-Microbiota Interactions in Health and Disease

The trillions of bacterial, fungal and viral microbes that live in and on us (our ‘microbiota’) have profound effects on the development and progression of diseases as diverse as inflammatory bowel disease, autoimmunity, metabolic syndrome, and autism. The long-term goal of the Palm lab is to understand the mechanisms by which the human microbiota interacts with and influences the host immune system, and the effects of this interaction on human physiology. We then use this knowledge to develop new therapeutic approaches to shape host-microbiota interactions to promote health and prevent disease. To achieve these goals, we develop and utilize novel high-throughput microbiota-profiling approaches, innovative microbiological tools, and sophisticated germ-free mouse models. For example, we are currently developing new technologies that will enable us to identify specific bacterial proteins and metabolites that mediate host-microbiota interactions with unprecedented speed. These studies will reveal the molecular mechanisms that mediate host-microbiota interactions and provide new avenues for the development of next-generation microbiota-targeted therapeutics.

 

PUBLISHED WORK

April 18, 2019

A FORWARD CHEMICAL GENETIC SCREEN REVEALS GUT MICROBIOTA METABOLITES THAT MODULATE HOST PHYSIOLOGY

Chen et al., 2019, Cell 177, 1217–1231 May 16, 2019 © 2019 Elsevier Inc. https://doi.org/10.1016/j.cell.2019.03.036